The Benefits of Exercise
It has been established with men with PCA, even when undertaking androgen deprivation (hormone therapy) that a combination of high-load resistance exercise and 20 min of aerobic exercise, 3 times a week, can:
- Both preserve and increase strength, muscle mass and reduce fat, even if the men are simultaneously undergoing radiotherapy .
- Reduce physiological distress and improve social functioning .
- Improve sexual function [2,3].
- Reduce fatigue [2,4].
- Help preserve bone strength and density (necessary against osteoporosis) .
- Be safely performed during radiotherapy, androgen deprivation, even in the presence of bone metastases .
- Can help preserve improve muscle and physical performance when performed prior to prostatectomy .
Newton RU, Mavropalias G, Fragala MS, Kraemer WJ, Häkkinen K, Taaffe DR, et al. Radiotherapy before or during androgen-deprivation therapy does not blunt the exercise-induced body composition protective effects in prostate cancer patients: A secondary analysis of two randomized controlled trials. Exp Gerontol 2021;151:111427. https://doi.org/10.1016/j.exger.2021.111427.
Cormie P, Galvão DA, Spry N, Joseph D, Chee R, Taaffe DR, et al. Can supervised exercise prevent treatment toxicity in patients with prostate cancer initiating androgen-deprivation therapy: a randomised controlled trial. BJU Int 2015;115:256–66. https://doi.org/10.1111/bju.12646.
Cormie P, Newton RU, Taaffe DR, Spry N, Joseph D, Akhlil Hamid M, et al. Exercise maintains sexual activity in men undergoing androgen suppression for prostate cancer: a randomized controlled trial. Prostate Cancer Prostatic Dis 2013;16:170–5. https://doi.org/10.1038/pcan.2012.52.
Taaffe DR, Newton RU, Spry N, Joseph D, Chambers SK, Gardiner RA, et al. Effects of different exercise modalities on fatigue in prostate cancer patients undergoing androgen deprivation therapy: a year-long randomised controlled trial. Eur Urol 2017;72:293–9. https://doi.org/10.1016/j.eururo.2017.02.019.
Taaffe DR, Galvão DA, Spry N, Joseph D, Chambers SK, Gardiner RA, et al. Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition. BJU Int 2019;123:261–9. https://doi.org/10.1111/bju.14505.
Galvão DA, Taaffe DR, Spry N, Cormie P, Joseph D, Chambers SK, et al. Exercise preserves physical function in prostate cancer patients with bone metastases. Med Sci Sports Exerc 2018;50:393–9. https://doi.org/10.1249/MSS.0000000000001454.
Singh F, Newton RU, Baker MK, Spry NA, Taaffe DR, Thavaseelan J, et al. Feasibility of presurgical exercise in men with prostate cancer undergoing prostatectomy. Integr Cancer Ther 2017;16:290–9. https://doi.org/10.1177/1534735416666373.